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. 2018 Mar 1;9:151. doi: 10.3389/fphys.2018.00151

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Copyright © 2018 de Anda-Jáuregui, Guo, McGregor and Hur.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heatmap of gene perturbation similarity. These heatmaps represent similarities in gene expression profiles induced by drugs obtained from the (A) Connectivity Map (CMap) and (B) Library of Integrated Network-based Cellular Signatures (LINCS) datasets. The color intensity is proportional to the similarity between the gene expression profiles of two drugs measured using the Spearman correlation. Drugs are ordered using non-supervised hierarchical clustering. In both panels, a larger cluster containing most drugs and two smaller clusters are shown. The clusters comprise drugs that do not necessarily share structural similarities.