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. 2018 Mar 1;9:151. doi: 10.3389/fphys.2018.00151

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Copyright © 2018 de Anda-Jáuregui, Guo, McGregor and Hur.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Toxic and therapeutic potential of the anti-inflammatory drug space. In these figures, drugs are classified based on their risk of producing an adverse drug reaction (ADR, measured as the node strength from the drug-ADR network) and their potential alternative therapeutic uses [measured as the degree in a drug-pathway network, either derived from (A) the Connectivity Map (CMap) or (B) Library of Integrated Network-based Cellular Signatures (LINCS)]. Each axis is divided by its median value. Point color and size are proportional to position in the x and y axes. Following this classification, drugs in the upper, left quarter are the best repositioning candidates, as they have the most effects on alternative pathways and the least risk for ADRs.