Figure 3. Model-Based Estimates of Treatment Effect on CES-D Score Over Time in Women With 0, 1, 2, or More Stressful Life Events (SLEs).

A significant effect of treatment is evident among the high-stress (n = 55; P = .005) but not low-stress (n = 72; P = .53) or moderate-stress (n = 46, P = .70) women. CES-D indicates Center for Epidemiological Studies–Depression Scale; TE+IMP, transdermal estradiol plus intermittent micronized progesterone.