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Influx of drug-specific cytotoxic T-cells and presentation of the drug bound to major histocompatibility complex Class I by keratinocytes result in apoptosis of the keratinocyte from perforin and granzyme release and the Fas-Fas ligand. These result in the formation of acantholysis and subcorneal blister. TCR: T-cell receptor. FADD: Fas associated death domain
