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Structural comparison of the peptide rapastinel with the spirocyclic β-lactam, ((2S, 3R)-3-hydroxy-2-((R)-5-isobutyryl-1-oxo-2,5-diazaspiro[3.4]octan-2-yl)butanamide) (NYX-2925). Spirocyclic β-lactam chemistry has been used to create a number of new molecules that mimic key properties of their parent peptides (Bittermann and Gmeiner, 2006).
