Skip to main content
. 2017 Nov 1;21(3):242–254. doi: 10.1093/ijnp/pyx096

Figure 6.

Figure 6.

NYX-2925 does not produce ketamine-like sedative/ataxic or discriminative stimulus effects. (A) NYX-2925 (1, 10, 100 mg/kg PO) did not produce sedation/ataxia in the fixed speed (16 RPM) RotaRod test. (B) Locomotor activity in the open field was not altered by NYX-2925 (1 mg/kg PO). (C,D) NYX-2925 does not substitute for ketamine as measured by (C) percentage ketamine-lever responding and (D) rates of responding for ketamine (10, 17, 30 mg/kg PO) and NYX-2925 (1, 10, 100 mg/kg PO) in rats trained to discriminate 5.6 mg/kg ketamine from saline. N=6–12 per group. * Fisher’s PLSD post hoc test vs vehicle.