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USP8 variants in corticotroph adenomas identified by NGS. Shown are variant allele frequencies of four tumors with USP8 variants detected by NGS. Frequencies were determined in the CLC Workbench program. A 98.5% mutant allele frequency in HYP029 confirms homozygosity or hemizygosity of the variant. HYP002 and HYP005 show two USP8 variants each.
