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. 2018 Mar 5;10:32. doi: 10.1186/s13148-018-0464-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Regional DNA methylation differs in airway fibroblasts isolated from donors with COPD versus non-COPD. a Summary of regional DNA methylation differences between DNA isolated from donors with and without COPD. Circle size represents the number of probes per regions. Orange = hypomethylated in COPD samples, blue = hypermethylated in COPD. b–f Detailed plots of the five regions with the greatest maximum difference in DNA methylation between DNA isolated from donors with and without COPD