Table 2.
Adjusted difference in adiposity measures at age 8 years per 10-fold-increase in urinary triclosan concentrations among HOME Study childrena,b
| Adiposity Outcome and Triclosan Measurement Timing | All, Adjusted Difference (95% CI) | Boys, Adjusted Difference (95% CI) | Girls, Adjusted Difference (95% CI) | EMM p-valuec |
|---|---|---|---|---|
| BMI z-score | ||||
| Prenatal | −0.03 (− 0.24, 0.19) | 0.07 (− 0.24, 0.38) | −0.12 (− 0.40, 0.16) | 0.37 |
| Average 1–5 years | 0.05 (− 0.27, 0.37) | 0.04 (− 0.50, 0.59) | − 0.12 (− 0.49, 0.25) | 0.50 |
| 8 Years | − 0.05 (− 0.23, 0.13) | − 0.08 (− 0.36, 0.20) | −0.13 (− 0.35, 0.09) | 0.96 |
| Waist Circumference (cm) | ||||
| Prenatal | − 1.3 (− 3.3, 0.6) | − 0.6 (− 3.0, 1.8) | − 1.7 (− 4.2, 0.7) | 0.62 |
| Average 1–5 years | 0.4 (− 2.4, 3.3) | 0.2 (− 4.0, 4.3) | − 1.6 (− 4.9, 1.7) | 0.51 |
| 8 Years | − 0.5 (− 2.1, 1.2) | − 1.0 (− 3.1, 1.1) | −1.3 (− 3.3, 0.6) | 0.71 |
| Body Fat % | ||||
| Prenatal | − 0.8 (− 2.2, 0.6) | − 0.6 (− 2.1, 0.9) | −0.6 (− 2.6, 1.3) | 0.79 |
| Average 1–5 years | 0.4 (− 1.7, 2.4) | − 0.4 (− 3.0, 2.1) | −1.1 (− 3.8, 1.6) | 0.82 |
| 8 Years | 0.0 (− 1.2, 1.2) | −0.8 (− 2.1, 0.5) | −0.4 (− 2.0, 1.2) | 0.73 |
aAll estimates are adjusted for maternal race, education, marital status, age at delivery, income, prenatal vitamin use, delivery method, maternal BMI, and prenatal serum cotinine concentrations. Both waist circumference and body fat percentage are also adjusted for child’s age. All urinary triclosan concentrations have been creatinine standardized
bFor prenatal analysis All: N = 220, Boys: N = 99, Girls: N = 121. For early childhood analysis All: N = 212, Boys: N = 94, Girls: N = 118. For age 8 year analysis All: N = 218, Boys: N = 99, Girls: N = 119
cEffect measure modification p-values were determined using a two sample z-test to compare the effect estimates in boys and girls