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. 2018 Mar 5;19:81. doi: 10.1186/s12859-018-2085-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Results of IntLIM applied to a breast cancer datase. a Clustering of Spearman correlations of 2842 identified gene-metabolite pairs(18,228 genes and 379 metabolites, with 61 tumor and 47 non-tumor samples) (FDR-adjusted p-value of interaction coefficient < 0.05 with Spearman correlation difference of > 0.5) in tumor and non-tumor tissue from breast cancer tissue. b GPT2 association with 2-hydroxyglutarate (FDR-adjusted p-value = 0.046, Normal Spearman Correlation = − 0.11, Tumor Spearman Correlation = 0.40). c Lack of association between 2-hydroxygutarate with MYC (FDR adj. p-value = 0.90, Normal Spearman Correlation = − 0.20, Tumor Spearman Correlation = 0.04)