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. 2018 Mar 5;11:12. doi: 10.1186/s13041-018-0355-x

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — ZBD-2-mediated regulation of the HPA axis hormone levels in the PPD models. a-d The CRH (a), ACTH (b), and CORT (c) levels were significantly increased and the 5-HT (d) level was obviously decreased in the sera of PPD models. ZBD-2 reversed the CRH, ACTH, CORT, and 5-HT to basal levels, which were blocked by PK11195 treatment. The effects of ZBD-2 were comparable to the effects of fluoxetine. n = 6 mice in each group. **p < 0.01 compared with the control; ^#p < 0.05, ^##p < 0.01 compared with the PPD model; ^$$p < 0.01 compared with the ZBD-2 group. PK: PK11195