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. 2018 Mar 6;10:28. doi: 10.1186/s13195-018-0358-y

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Hypothetical working model of reserve. Education is associated with higher efficiency (i.e., small-worldness) of functional brain networks, which is in turn associated with better cognitive performance. The association between education and functional network efficiency is mediated by the left frontal cortex (LFC) hub region (yellow sphere) that modulates the efficiency of downstream networks