Fig. 4.

HIV-infected individuals with short ‘S’ HO-1 (GT)n alleles have significantly lower CNS expression of markers of type I interferon responses and T-lymphocyte activation. Prefrotanal cortex RNA expression of neuroimmune markers was compared between HIV-infected subjects (without HIVE) with a short ‘S’ HO-1 (GT)n allele (SS, SM, SL) and those without a short ‘S’ allele (MM, ML, LL). Neuroimmune markers analyzed were a MX1, b ISG15, c IRF1, d CD38, e GZMB, f CD8A, g CD68, h CD163, i CD19, j PECAM1, and k VWF. Lines and error bars indicate median ± 95% confidence interval of log₁₀ transformed RNA expression data. Red median lines and errors bars denote significant differences. Differences between groups were analyzed by Mann-Whitney test. n.s., not significant