Fig. 6.

Prefrontal cortex type I interferon responses and T-lymphocyte activation marker expression trends lower in HIV-infected Caucasian and African American individuals with short ‘S’ HO-1 (GT)n alleles. Prefrotanal cortex RNA expression of neuroimmune markers was compared between HIV-infected subjects (without HIVE) with a short ‘S’ HO-1 (GT)n allele (SS, SM, SL) and those without a short ‘S’ allele (MM, ML, LL) in self-identifying Caucasian and African American subgroups. Neuroimmune markers analyzed were a MX1, b ISG15, c IRF1, d CD38, and e GZMB, those that significantly associated with the HO-1 (GT)n polymorphism in the full HIV+ cohort. Lines and error bars indicate median ± 95% confidence interval of log₁₀ transformed RNA expression data. Red median lines and errors bars denote significant differences. Differences in expression between subjects with short ‘S’ alleles and those without ‘S’ alleles in Caucasian and African American subgroups were analyzed by Mann-Whitney test