Fig. 1.

Confirming the role of RBPJL in regulating the expression of pancreatic exocrine enzymes. 266-6 cells (mouse pancreatic acinar cells) were transfected with either control siRNA or siRNA targeting mouse Rbpjl. Results shown are mean ± SD from four independent experiments. % reduction is the percent reduction in expression of target genes in cells treated with Rbpjl siRNA compared to basal (untreated cells). No effect was seen on the expression of B2m a housekeeping gene not regulated by Rbpjl. Statistical association was determined using an unpaired t-test. ***P < 0.001, **P < 0.01, NS not significant, NR no reduction. Gene expression (mRNA) levels were normalized to the expression of Tbp