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. 2018 Jan 4;26(2):238–246. doi: 10.1038/s41431-017-0062-6

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© European Society of Human Genetics 2017

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. If you remix, transform, or build upon this article or a part thereof, you must distribute your contributions under the same license as the original. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/.

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Fig. 4 — Functional assessment of RBPJL p.(Thr280Met) in mouse pancreatic acinar cells. The data show the effect of RBPJL Thr280 (light gray) and Met280 (dark gray) on the expression of Cel, a Rbpjl target gene, in mouse pancreatic acinar cell line (266-6). As a control, the effect on the expression of Gapdh, which is not a target gene, was also assessed. Expression levels of RBPJL, PTF1A and mouse Rbpjl are also shown. Data shown are mean ± sd from six different experiments, except for mouse Rbpjl which is the mean of four experiments. ***P-value < 0.0001, NS not significant, EV pCMV6 empty vector. Gene expression (mRNA) levels were normalized to the expression of Tbp