Fig. 1.

Burden analysis. Typical Rolandic epilepsy is represented as RE, atypical rolandic epilepsy as ARE and RE plus ARE as ROLANDIC. On the x axis, the odds ratios in cases vs controls are given. The names of the variant classes are given on the y axis. Each panel represents a different dataset. The dashed vertical line represents the expected odds ratio of 1. The horizontal lines indicate 95% confidence intervals. a Assessment of risk for deleterious variants in GRIN2A against two control groups (ExAC and In-house). The values on top of each point represent multiple-testing corrected p-values, the ones in red are significant p-values and the ones in black are the p-values that are not significant after multiple-testing correction. The odds ratios are restricted to a maximum value of 50. b Exome-wide burden analysis by different variant classes. The values on top of each point represent the p-value. Synonymous variants serve as a control functional group (colour figure online)