Table 4.
Mean ± SD of Ins concentrations (mmol/L of brain water) and Ins/tCr ratios
| Dose 1 | Dose 2 | Dose 3 | Arithmetic mean | |||
|---|---|---|---|---|---|---|
| Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | |||
| Ins | BG | Isoflurane | 7.931 ± 0.343 | 7.983 ± 0.589 | 7.730 ± 0.824 | 7.876 ± 0.529 |
| Sevoflurane | 8.365 ± 0.816 | 8.470 ± 0.780 | 8.344 ± 0.710 | 8.393 ± 0.701 | ||
| Propofol | 8.033 ± 0.561 | 8.056 ± 0.778 | 8.109 ± 0.646 | 8.100 ± 0.601 | ||
| Alfaxalone | 8.325 ± 0.606 | 8.446 ± 0.689 | 8.605 ± 0.487 | 8.459 ± 0.470 | ||
| PL | Isoflurane | 7.679 ± 0.996 | 8.176 ± 0.861 | 8.070 ± 0.716 | 8.016 ± 0.835 | |
| Sevoflurane | 8.165 ± 0.445 | 8.367 ± 0.528 | 8.131 ± 0.485 | 8.221 ± 0.414 | ||
| Propofol | 8.178 ± 1.075 | 7.976 ± 1.266 | 7.833 ± 1.439 | 7.992 ± 1.196 | ||
| Alfaxalone | 7.967 ± 1.103 | 8.177 ± 1.078 | 8.188 ± 0.888 | 8.111 ± 0.954 | ||
| OL | Isoflurane | 8.005 ± 0.885 | 8.233 ± 0.871 | 8.077 ± 1.171 | 8.016 ± 1.087 | |
| Sevoflurane | 8.362 ± 0.620 | 8.588 ± 0.554 | 8.342 ± 0.677 | 8.431 ± 0.579 | ||
| Propofol | 8.382 ± 0.611 | 8.455 ± 0.749 | 8.336 ± 0.593 | 8.501 ± 0.752 | ||
| Alfaxalone | 8.524 ± 0.649 | 8.449 ± 0.629 | 8.523 ± 0.572 | 8.499 ± 0.591 | ||
| Ins/tCr | BG | Isoflurane | 1.365 ± 0.114 | 1.299 ± 0.082 | 1.331 ± 0.100 | 1.326 ± 0.075 |
| Sevoflurane | 1.389 ± 0.132 | 1.333 ± 0.137 | 1.336 ± 0.095 | 1.353 ± 0.103 | ||
| Propofol | 1.351 ± 0.124 | 1.335 ± 0.112 | 1.353 ± 0.114 | 1.307 ± 0.167 | ||
| Alfaxalone | 1.319 ± 0.108 | 1.334 ± 0.099 | 1.340 ± 0.110 | 1.331 ± 0.081 | ||
| PL | Isoflurane | 1.417 ± 0.173 | 1.462 ± 0.145 | 1.439 ± 0.112 | 1.443 ± 0.136 | |
| Sevoflurane | 1.510 ± 0.135 | 1.502 ± 0.084 | 1.457 ± 0.121 | 1.490 ± 0.107 | ||
| Propofol | 1.459 ± 0.221 | 1.451 ± 0.266 | 1.431 ± 0.271 | 1.440 ± 0.242 | ||
| Alfaxalone | 1.462 ± 0.214 | 1.509 ± 0.215 | 1.525 ± 0.211 | 1.498 ± 0.200 | ||
| OL | Isoflurane | 1.203 ± 0.081 | 1.205 ± 0.092 | 1.245 ± 0.113 | 1.220 ± 0.103 | |
| Sevoflurane | 1.242 ± 0.090 | 1.258 ± 0.077 | 1.228 ± 0.115 | 1.243 ± 0.089 | ||
| Propofol | 1.235 ± 0.056 | 1.287 ± 0.197 | 1.120 ± 0.326 | 1.256 ± 0.232 | ||
| Alfaxalone | 1.262 ± 0.098 | 1.259 ± 0.100 | 1.304 ± 0.160 | 1.275 ± 0.113 | ||
Mean ± SD for the three different doses and the arithmetic mean of the three doses for isoflurane, sevoflurane, propofol and alfaxalone in basal ganglia (BG), parietal lobe (PL) and occipital lobe (OL).