Table 6.
Baseline | Measurement 1 | Measurement 2 | Measurement 3 | ||
---|---|---|---|---|---|
Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | ||
pH | Isoflurane | 7.38 ± 0.04A | 7.35 ± 0.04 | 7.37 ± 0.05 | 7.38 ± 0.02AB |
Sevoflurane | 7.39 ± 0.02AB | 7.35 ± 0.02 | 7.36 ± 0.02 | 7.39 ± 0.04A | |
Propofol | 7.41 ± 0.02B | 7.33 ± 0.03* | 7.33 ± 0.04* | 7.30 ± 0.04*B | |
Alfaxalone | 7.39 ± 0.05AB | 7.34 ± 0.03 | 7.35 ± 0.03 | 7.35 ± 0.03AB | |
HCO3− [mmol L− 1] |
Isoflurane | 21.01 ± 1.73A | 20.44 ± 1.74AB | 20.00 ± 1.37AB | 21.00 ± 1.57AB |
Sevoflurane | 22.22 ± 1.46AB | 20.32 ± 1.09*A | 20.86 ± 0.99AB | 20.66 ± 1.24AB | |
Propofol | 22.01 ± 1.87B | 20.10 ± 1.31*A | 19.67 ± 1.34*A | 18.58 ± 1.11*A | |
Alfaxalone | 21.71 ± 1.59AB | 21.73 ± 1.07B | 22.00 ± 1.04B | 21.94 ± 0.92B | |
sBE [mmol L− 1] |
Isoflurane | −2.77 ± 1.31A | −4.27 ± 1.95AB | −4.38 ± 1.85AB | −3.30 ± 1.59AB |
Sevoflurane | −2.02 ± 1.54AB | −4.30 ± 1.08*AB | −3.70 ± 1.09AB | −3.56 ± 1.16*B | |
Propofol | − 1.84 ± 1.70B | − 4.86 ± 1.46*A | −5.27 ± 1.55*A | −6.67 ± 1.41*A | |
Alfaxalone | −2.5 ± 1.33AB | − 3.08 ± 1.06B | −2.78 ± 1.05B | −2.85 ± 0.98B | |
Na+ [mmol L− 1] |
Isoflurane | 148.2 ± 1.48 | 147.7 ± 1A | 146.8 ± 1*B | 147.25 ± 1.2AB |
Sevoflurane | 147.9 ± 1.66 | 148.1 ± 1.8 | 146.2 ± 2.2*A | 146.2 ± 1.6*A | |
Propofol | 147.2 ± 1.48 | 147.33 ± 1.7A | 147.6 ± 1.8A | 148.89 ± 1.6* | |
Alfaxalone | 147.67 ± 1.66 | 149 ± 1.1* | 150.7 ± 3.1* | 149.8 ± 0.9* | |
Glucose [mmol L− 1] |
Isoflurane | 5.29 ± 0.25 | 5.84 ± 0.61B | 6.13 ± 0.65A | 6.00 ± 0.49*ABC |
Sevoflurane | 5.29 ± 0.37 | 5.19 ± 0.21AC | 5.56 ± 0.40A | 5.59 ± 0.42A | |
Propofol | 5.20 ± 0.28 | 4.98 ± 0.38A | 4.97 ± 0.27 | 4.92 ± 0.30B | |
Alfaxalone | 5.65 ± 0.63 | 5.83 ± 0.49BC | 6.17 ± 0.93A | 6.31 ± 0.66C | |
Lactate [mmol L− 1] |
Isoflurane | 1.06 ± 0.40A | 2.03 ± 0.94*A | 2.10 ± 0.69*A | 1.97 ± 0.78 |
Sevoflurane | 1.01 ± 0.30AB | 1.61 ± 0.56AB | 1.89 ± 0.74*AB | 1.58 ± 0.77 | |
Propofol | 1.01 ± 0.33B | 1.12 ± 0.34B | 1.31 ± 0.55AB | 1.41 ± 0.23 | |
Alfaxalone | 0.95 ± 0.49AB | 0.86 ± 0.83B | 1.03 ± 0.64B | 1.14 ± 0.57 | |
Triglycerides [mmol L− 1] |
Isoflurane | 0.53 ± 0.17A | 0.36 ± 0.13*AB | 0.29 ± 0.13*A | 0.36 ± 0.24AB |
Sevoflurane | 0.53 ± 0.14AB | 0.36 ± 0.14A | 0.29 ± 0.11*A | 0.27 ± 0.09* | |
Propofol | 0.55 ± 0.12B | 2.82 ± 1.02* | 2.97 ± 1.21* | 3.46 ± 1.07*A | |
Alfaxalone | 0.59 ± 0.16AB | 0.22 ± 0.06*B | 0.19 ± 0.07*A | 0.20 ± 0.06*B |
Mean ± SD of the results of blood gas analysis (pH, HCO3- [mmol L-1], sBE [mmol L-1]) and plasma glucose [mmol L-1], −lactate [mmol L-1] and -triglycerides [mmol L-1] before anaesthesia, after measurement period 1, 2 and 3; * p < 0.05 compared to baseline within one Treatment, Different alphabetical superscripts differ in between treatments at one measurementpoint (p < 0.05)