FIG 4.
Combined effect of CysLT1R antagonist and EP3 antagonist on synergistic responses to LTD4 and PGE2. LAD2 cells (A–C) and hMCs (D and E) were preincubated with MK571 (1 μmol/L) and L-798 (100 nmol/L) separately or in combination and treated with LTD4 (0.5 μmol/L) ± PGE2 (0.5 μmol/L), and c-fos (Fig 4, A, B, D, and E) and MIP-1β (Fig 4, C) were analyzed. *P < .05, **P < .01, and ***P < .001.