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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: J Mol Cell Cardiol. 2018 Jan 4;115:104–114. doi: 10.1016/j.yjmcc.2018.01.003

Figure 3. PKC activation disrupts Ca2+ handling properties in cardiomyocytes.

Figure 3

A, Schematic of experimental protocol. B, Representative cytosolic Ca2+ images under 1-Hz field in cultured cardiomyocytes after treatment as diagrammed in (A). The fluorescence intensity of Ca2+ imaging was normalized to baseline (F0). The red lines overlapping on Ca2+ images show the profile at the moment of Ca2+ transient firing on the scanning line in a point-by-point manner. A straighter line means better synchronization of the Ca2+ transients. C–D, Average data of the amplitude (C) and dyssynchronous index (D) of Ca2+ transients. n=53, 57, 46 and 36 cells, per group, respectively. ** p <0.01.