Table I.
Baseline demographic and clinical characteristics of rare/never drinkers and drinkers
| MEN (n = 168) | Rare/never drinkers (n = 72) | Moderate Drinkers (n = 61) | Heavy Drinkers (n = 35) | Drinking effect p-value |
|---|---|---|---|---|
| Age, years (SD) | 83.1 (8.0) | 81.4 (8.3) | 80.6 (6.9) | 0.23 |
| Education, years (SD) | 15.2 (3.0) | 16.0 (2.3) | 16.3 (3.4) | 0.15 |
| MMSE score (SD) | 28.3 (1.5) | 28.2 (1.5) | 28.2 (1.7) | 0.96 |
| Caucasian, % (n) | 94% (68) | 98% (60) | 86% (30) | 0.0401 |
| Cumulative Illness Rating Scale score (SD) | 20.7 (3.3) | 19.9 (3.3) | 19.7 (2.75) | 0.54 |
| ApoE4, # (%) | 12 (16.7%) | 14 (23.0%) | 6 (17.1%) | 0.53 |
| BMI (kg/m2) | 26.4 (3.7) | 25.4 (2.8) | 26.9 (4.0) | 0.11 |
| Diabetic, % (n) | 12.5% (9) | 9.8% (6) | 8.5% (3) | 0.85 |
| Hypertensive, % (n) | 51.3% (37) | 57.4% (35) | 65.7% (23) | 0.39 |
| Reported # of drinks weekly | - | 5.2 (2.5) | 14.2 (7.5) | <0.001 |
| WOMEN (n = 318) | Rare/never drinkers (n = 183) | Moderate Drinkers (n = 85) | Heavy Drinkers (n = 50) | Drinking effect p-value |
|---|---|---|---|---|
| Age, years (SD) | 83.7 (6.6) | 83.9 (6.5) | 79.0 (8.4) | 0.0022 |
| Education, years (SD) | 14.2 (2.5) | 14.8 (2.4) | 15.4 (2.8) | .0113 |
| MMSE score (SD) | 28.4 (1.6) | 28.5 (1.4) | 28.9 (1.2) | 0.10 |
| Caucasian, % (n) | 92% (168) | 92% (78) | 90% (45) | 0.91 |
| Cumulative Illness Rating Scale score (SD) | 20.4 (3.4) | 20.4 (3.5) | 20.5 (3.6) | 0.99 |
| ApoE4, # (%) | 27 (14.8%) | 21 (24.7%) | 15 (30.0%) | 0.0244 |
| BMI (kg/m2) | 26.0 (4.9) | 25.7 (4.6) | 25.7 (4.9) | 0.86 |
| Diabetic, % (n) | 10.9% (20) | 9.4% (8) | 14.0% (7) | 0.70 |
| Hypertensive, % (n) | 61.7% (113) | 70.6% (60) | 68.0% (34) | 0.34 |
| Reported # of drinks weekly | - | 4.7 (1.9) | 15.7 (6.4) | <0.001 |
4 (5.6%) of the rare/never drinkers did not have ApoE4 genotype identified.
7 (11.5%) of the moderate drinkers did not have ApoE4 genotype identified.
5 (14.3%) of the heavy drinkers did not have their ApoE4 genotype identified.
significant contrast between heavy drinkers and moderate drinkers (p=0.023)
12 (6.66%) of the rare/never drinkers did not have ApoE4 genotype identified.
7 (8.3%) of the drinkers did not have ApoE4 gene identified.
2 (4.0%) of the heavy drinkers did not have ApoE4 gene identified
significant contrasts between heavy drinkers and both moderate drinkers and rare/never drinkers (p<0.001)
significant contrast between heavy drinkers and rare/never drinkers (p=0.005)
significant contrast between heavy drinkers and rare/never drinkers (p=0.028)
Data are presented as means (Standard Deviation; SD) unless otherwise indicated.
Statistical comparisons were made using one-way ANOVAs, with the exception of race/Caucasian and ApoE4, which were determined with the Fisher test. Specific contrasts between drinking groups were evaluated with pairwise t-tests and pairwise Fisher tests respectively