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. Author manuscript; available in PMC: 2018 Mar 6.
Published in final edited form as: Cell. 2017 Feb 23;168(5):758–774. doi: 10.1016/j.cell.2017.01.025

Figure 1. Contribution of Genetic Heritage and Modern Lifestyle to Body Weight.

Figure 1

Body weight and metabolic health are determined by the interaction of genetic susceptibility and environmental influences. Major contributors to human adiposity include dietary quality and palatability, exercise habits, smoking, alcohol consumption, age, sleep, and pharmacology. These factors both directly and indirectly impact energy intake and/or energy expenditure to govern energy homeostasis.