Table 2.

Control of hyperglycemia by leflunomide in ob/ob mice^†

Drug	Number of mice (N)	Blood glucose concentration (mg/dL)			Body weight (g)				Food intake (g/d)	p value*
		Before	After	p value	Before	After	Change	p value*
Vehicle	6	234±16	252±22	0.697	47.8±2.9	48.0± 3.1	0.12±0.21		4.9± 0.23
Leflunomide	7	275±12	111±6	0.001	48.4±0.48	48.5±0.51	−0.02±0.13	0.252	5.0 ±0.09	0.687
Uridine	4	210±12	253±15	0.153	48.7± 0.68	48.5 ±0.69	−0.02±0.08	0.793	4.9 ±0.07	1.000
Lef + Uridine	4	222±15	97±15	0.021	48.5±1.21	48.4±1.06	−0.3±0.04	0.385	4.8 ±0.04	0.272

^†ob/ob mice (male, 8–10 wks) were treated with the vehicle (1.5% CMC, daily, gavage), leflunomide (35 mg/kg, daily, gavage), uridine (2 g/kg, twice daily, i.p.) or leflunomide (35 mg/kg, daily, gavage) + uridine (2 g/kg, twice daily, i.p.) for three days. After fasting for 6 hr, blood glucose levels were measured and statistically analyzed by a paired Student t test. Body weight of mice were measured before and 3 days after treatment. Food consumption was measured on individual mouse in a separate cage on day 3 after treatment.

^*Compared to the vehicle control.