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Result of global sensitivity analysis, using SOBOL method, highlighting the sensitive parameters of platform PBPK model for ADC (T-DM1) and UD (unconjugated DM1) PK. Kdeg: degradation rate constant, Kdec: dissociation rate constant, CLh: hepatic clearance of DM1, FCRN: FcRn concentration estimated from mAb PBPK model, fup: fraction of DM1 unbound in plasma, FR: fraction of ADC recycled by FCRN, kp-tissue: partition coefficient for a tissue
