Table II.
Partition coefficients derived from observed concentrations and model-estimated permeability surface values for rat
| Tissues | Partition coefficient for rat* | Partition coefficient for human* | Rat PS (CV%) (L/h) |
|---|---|---|---|
| Blood cells | 106.9 | 40.1 | 294.5 (Qplasma × 100) |
| Lung | 1043.7 | 333.6 | 0.52 (10.7) |
| Heart | 368.9 | 138.8 | 0.14 (9.8) |
| Kidney | 2550.9 | 955.0 | 0.63 (7.4) |
| Brain | 20.9 | 7.8 | 0.003 (11.9) |
| Muscle | 544.5 | 202.9 | 1.6 (4.9) |
| Marrow | 2.1 | 0.77 | 0.015 (39.9) |
| Thymus | 630.5 | 236.3 | 0.0007 (7.5) |
| Skin | 279.3 | 104.7 | 0.19 (8.5) |
| Fat | 219.0 | 82.3 | 0.11 (7.3) |
| Small intestine | 782.6 | 293.2 | 0.33 (7.2) |
| Large intestine | 723.9 | 272.3 | 0.18 (7.2) |
| Spleen | 1330.4 | 498.3 | 0.26 (8.6) |
| Liver | 1889.2 | 754.7 | 12.4 (48.3) |
| Other | 479.8 | 184.2 | 0.10 (8.2) |
| Pancreas | 1 (no data) | 1 (no data) | Qpancreasplasma |
| CLhepatic | 1.53 (5.5) |
*
Adjusted for fraction unbound in plasma (fup) and cellular volume (cellular volume/total volume)