Table 2. Multivariate Analysis of Prognostic Factors for Overall and Disease-Specific Survival .
| Variable | Adjusted Hazard Ratio (95% CI) (n = 1015) |
|
|---|---|---|
| Overall Survival | Disease-Specific Survival | |
| Sex | ||
| Male | 1 [Reference] | 1 [Reference] |
| Female | 2.07 (1.42-2.96) | 1.14 (0.40-3.16) |
| Age, y | ||
| <45 | 1 [Reference] | 1 [Reference] |
| ≥45 | 3.12 (1.54-7.03) | 1.31 (0.72-1.41) |
| Tumor morphologic type | ||
| Papillary | 1 [Reference] | 1 [Reference] |
| Papillary, follicular variant | 0.94 (0.61-1.38) | 1.09 (0.04-11.3) |
| Papillary, follicular poorly differentiated | 4.03 (0.71-8.43) | 3.08 (0.08-13.6) |
| Change in the risk of death per 1-cm tumor size | 1.71 (0.41-7.79) | 1.37 (1.07-1.81) |
| Extrathyroid extension to the strap muscles | ||
| Absent | 1 [Reference] | 1 [Reference] |
| Present | 1.01 (0.52-1.89) | 3.25 (1.08-10.11) |
| Pathologic T classification | ||
| T1 | 1 [Reference] | 1 [Reference] |
| T2 | 1.46 (0.55-4.51) | 1.51 (1.1-3.9) |
| T3 | 1.91 (0.91-1.14) | 2.67 (5.71-1.72) |
| T4 | 1.94 (0.93-4.21) | 12.6 (1.72-4.73) |
| Pathologic N classification | ||
| N1 | 1 [Reference] | 1 [Reference] |
| N1a | 0.94 (0.35-2.43) | 0.95 (0.18-6.61) |
| Nb | 1.36 (0.49-4.06) | 6.21 (0.96-44.61) |
| M classification | ||
| 0 | 1 [Reference] | 1 [Reference] |
| 1 | 2.12 (1.12-3.7) | 3.14 (1.1-9.81) |
| Extracapsular spread | ||
| Absent | 1 [Reference] | 1 [Reference] |
| Present | 2.28 (1.12-4.44) | 4.36 (1.2-20.61) |
| Treatment group | ||
| Surgery | 1 [Reference] | 1 [Reference] |
| Surgery + radioactive iodine | 2.15 (1.31-3.17) | 3.14 (0.64-13.5) |
| Lymph node density | ||
| ≤0.19 | 1 [Reference] | 1 [Reference] |
| >0.19 | 1.96 (1.24-4.11) | 4.11 (2.11-8.97) |