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Silencing glutamatergic VMH neurons promotes negative energy balance in females. Summary of the relative distribution of VMHVGLUT2 and VMHERα,VGLUT2 neurons and the metabolic consequences resulting from genetic knockout of either ERα or VGLUT2. Opposing metabolic phenotypes observed in mutant female mice following deletion of ERα or VGLUT2 in the VMH suggest that ERα signaling reduces rather than enhances glutamaterigic output from the VMHvl
