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. Author manuscript; available in PMC: 2018 Mar 6.
Published in final edited form as: Adv Exp Med Biol. 2017;1043:199–213. doi: 10.1007/978-3-319-70178-3_10

Table 1.

Comparison of mouse models that eliminate ERα in the VMHvl

Phenotype Nkx2-1Sf1-Cre Esr1Sf1-Cre Esr1Nkx2-1Cre
ERα expression ++ + −
Tac1 expression ++ +++ +++
# of VMHvl neurons ++ +++ +++
Reproduction Fertile Infertile Infertile
Body weight (chow) Increase Transient increase No change
BAT thermogenesis Normal Lower Lower
Food intake Normal Normal Normal
Locomotion Decreased Trends lower Decreased
+++

= Wild-type levels. References for the table: Xu et al. (2011), Correa et al. (2015) and unpublished data (H.A.I)