Table 1.
Phenotype | Nkx2-1Sf1-Cre | Esr1Sf1-Cre | Esr1Nkx2-1Cre |
---|---|---|---|
ERα expression | ++ | + | − |
Tac1 expression | ++ | +++ | +++ |
# of VMHvl neurons | ++ | +++ | +++ |
Reproduction | Fertile | Infertile | Infertile |
Body weight (chow) | Increase | Transient increase | No change |
BAT thermogenesis | Normal | Lower | Lower |
Food intake | Normal | Normal | Normal |
Locomotion | Decreased | Trends lower | Decreased |
= Wild-type levels. References for the table: Xu et al. (2011), Correa et al. (2015) and unpublished data (H.A.I)