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. 2017 Dec 28;9(11):9632–9644. doi: 10.18632/oncotarget.23745

Figure 6. Model showing the role of IL-2 in maintaining BM erythropoiesis.

Figure 6

(A) IL-2 signals are essential to lower the integrin-cAMP-NFAT signaling, and in facilitating optimal KLF1 and EpoR expression, which results in normal erythropoiesis in the BM. (B) Deficiency in IL-2 or of any component of IL-2 signaling pathway leads to upregulated integrin-cAMP-NFAT signaling as well as suppressed Klf1 and Epor expression. Both these defects combinedly result in enhanced cell death of immature erythrocytes leading to the development of severe anemia in IL-2 signaling-deficient mice. Grey dashed arrow represents lack of Epo signaling.