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. 2018 Jan 3;9(11):9825–9837. doi: 10.18632/oncotarget.23934

Figure 4. The high expression of IL-17-producing T cells was positively correlated with VEGF-A production in HNC and to facilitate OSCC cells proliferation.

Figure 4

(A) OSCC cells were cultured in the presence of 100 ng/mL rhIL-17 for 48 h and the VEGF-A content from culture supernatants were analyzed for by ELISA. (B) OSCC cells were treated with or without different concentrations of recombinant VEGF-A (0.25-2 ng/mL) for 48 h, and cell proliferation was determined by MTT assay. (C) Correlations between the level of IL-17-producing T cells (Th17 and Tc17) and plasma VEGF-A in HNC patients (n = 84) were analyzed by Pearson correlation test. (D) The production of VEGF-A in plasma from HNC patients (early and late stage) and healthy donors were analyzed by ELISA. Data are representatives of at least three experiments and shown as the mean ± SEM.