Table 2. Cytocidal activities of B2RAs and standard chemotherapeutic agents against MDA-MB-231 cells.
| Agents | IC50 values |
|---|---|
| HOE 140 | > 100 μM |
| FR173657 | 20 ± 1 μM |
| NG68 | 45 ± 1 μM |
| NG134 | > 100 μM |
| BCNU (carmustine) | 62 ± 1 μM |
| Adriamycin (doxorubicin) | 2 ± 1 μM |
| Carboplatin | > 100 μM |
| Temozolomide (Temodar) | > 100 μM |
| Paclitaxel (Taxol) | 10 ± 1 μM |
Data represent means ± s.e.m. (n = 6 to 8 experiments). Cell viability was established by the MTT assay after 72h drug exposure. IC50 values were calculated from complete concentration response-curve from no response to 80–100% cell death.