Figure 3. CXCR4 protein expression in vestibular schwannomas.

Protein lysates were isolated from vestibular schwannoma samples and subjected to Western blotting analysis. Specific antibodies detected at least four CXCR4 isoforms of approximately 190 kDa, 72 kDa, 55 kDA, and 42 kDa (arrows), reflecting the structural heterogeneity of CXCR4 in tumors. γ-tubulin served as a loading control. Results are shown for 8 representative tumors (No. 50–57) of the total sample (n = 60) and for 4 representative nerves (No. N7–N10) for the control group (n = 10).