Figure 2. Induction of apoptosis and alteration of proteasome activities in multiple myeloma cells treated with syringolog-1.

(A) Percent specific apoptosis in multiple myeloma (MM) cell lines and bortezomib (Btz)-resistant cell lines was detected after incubation with 10 nM of syringolog-1 for 16 h. ^* represents statistically significant (p < 0.05) by Dunnett’s post-test. (B) MM cell lines were subjected to the analysis of proteasome activities after incubation with 10 nM syringolog-1 (Sy) for 6 h. (C) Btz-resistant MM cell lines and their parental cells were similarly analyzed of proteasome activities. ^* represents statistically significant by Student’s t-test (p < 0.05).