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. Author manuscript; available in PMC: 2018 Apr 21.
Published in final edited form as: Org Lett. 2017 Apr 4;19(8):1966–1969. doi: 10.1021/acs.orglett.7b00494

Scheme 1. Scope of Pd-Catalyzed Amidation of α-Methylene-β-lactonesa with Various Aminesb.

Scheme 1

aFor the syntheses of the α-Methylene-β-lactones see the Supporting Information. bGeneral conditions: 0.1 to 0.2 mmol 1 (1 equiv), amine (1.1 equiv), Pd(OAc)2 (5 mol %), PPh3 (15 mol%) in DCM (0.2 M) at rt or 45 °C for 24 h. For aryl amines: 2-4 equiv of aryl amine was used in DCM (0.5 M) at 45 °C. c1.0 mmol scale.