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Mechanisms of CO for repair process in traumatic brain injury. CO, provided from CORM-3 or CO gas, may offer a novel therapeutic approach for traumatic brain injury by preventing pericyte cell death from ROS-dependent signaling, resulting in the activation of redox-sensitive transcription factor HIF-1α, consequently leading to cleaved caspase 3-mediated apoptosis. Moreover, CO therapy may promote pericyte-NSC crosstalk to boost nNOS/NO-mediated neurogenesis.
