Fig. 1.

Effects of diosmetin on LPS-induced lung injury in BALB/c mice. (A) H&E staining of lung tissue section (original magnification, ×200). Lungs from each experimental group (n=5) were obtained 12 h after LPS challenge, prepared and stained with H&E: (a) control, (b) diosmetin (25 mg/kg), (c) LPS (0.5 mg/kg), (d) LPS+diosmetin (5 mg/kg), (e) LPS+diosmetin (25 mg/kg) and (f) LPS+Dex (5 mg/kg). (B) Lung mean injury score. The lung injury score was determined following a five-point scale from 0 to 4 as follows: 0, 1, 2, 3, and 4 represent no damage, mild damage, moderate damage, severe damage, and very severe damage, respectively. Data was expressed as means ± SEM. n=5. ^**p<0.01 vs the control group. ^##p<0.01 vs the LPS group.