Fig. 1.

Protective effect of CO against 6-OHDA-induced cytotoxicity and apoptosis in C6 cells (A) Cells were treated with 6-OHDA (150 μM) and various concentrations of CORM-2 for 24 h and cell viability was measured by MTT assay. iCORM stands for inactive CORM which is CO-depleting molecule. (B) Apoptotic cell death was measured by TUNEL staining. (a) control; (b) 6-OHDA (150 μM) alone; (c) 6-OHDA (150 μM)+CORM-2 (10 μM); (d) 6-OHDA (150 μM)+CORM-2 (100 μM). ^*p<0.05 and ^**p<0.01 compared by 6-OHDA treatment alone and ^##p<0.01 compared by co-treatment of 6-OHDA and CORM-2.