Table 2. Comparison of metabolites obtained by ¹H-NMR spectroscopy between patient groups classified by the presence of lymph node metastasis and lateral lymph node metastasis.

Metabolite concentration (mM)	LN metastasis		P-value	Lateral LN metastasis		P-value
	(+)	(-)		(+)	(-)
Isoleucine	0.02 (0.01–0.47)	0.03 (0.00–0.47)	0.821	0.02 (0.01–0.16)	0.02 (0.00–0.47)	0.924
Leucine	0.05 (0.01–0.16)	0.06 (0.01–1.02)	0.880	0.05 (0.01–0.41)	0.05 (0.01–1.02)	0.761
Valine	0.06 (0.02–0.34)	0.06 (0.02–0.79)	0.940	0.05 (0.02–0.34)	0.06 (0.02–0.80)	0.642
Lactate	1.70 (0.61–10.51)	1.57 (0.39–7.11)	0.328	1.66 (0.61–10.51)	1.70 (0.39–7.11)	0.500
Threonine	0.07 (0.04–2.97)	0.08 (0.03–0.97)	0.873	0.07 (0.04–2.97)	0.08 (0.03–0.97)	0.518
Alanine	0.15 (0.04–0.58)	0.14 (0.03–1.50)	0.940	0.13 (0.04–0.58)	0.16 (0.03–1.50)	0.635
Uracil	0.02 (0.01–0.09)	0.02 (0.01–0.12)	0.461	0.03 (0.01–0.09)	0.16 (0.01–0.12)	0.218
Lysine	0.07 (0.02–0.56)	0.10 (0.01–1.15)	0.918	0.12 (0.02–0.56)	0.06 (0.01–1.15)	0.337
Glutamate	0.25 (0.08–2.51)	0.29 (0.04–2.53)	0.665	0.25 (0.10–0.56)	0.25 (0.04–2.53)	0.601
Methionine	0.04 (0.01–0.16)	0.04 (0.01–0.25)	0.397	0.04 (0.01–0.16)	0.04 (0.01–0.25)	0.655
Aspartate	0.07 (0.02–0.52)	0.06 (0.01–0.67)	0.288	0.07 (0.02–0.52)	0.07 (0.01–0.67)	0.464
Choline	0.03 (0.01–0.22)	0.03 (0.01–0.19)	0.714	0.03 (0.01–0.22)	0.03 (0.01–0.19)	0.635
Phosphocholine	0.19 (0.04–1.04)	0.20 (0.05–0.72)	0.925	0.21 (0.04–0.99)	0.19 (0.04–1.04)	0.655
Glycerophosphocholine	0.06 (0.02–616.00)	0.07 (0.02–0.25)	0.880	0.06 (0.03–0.41)	0.06 (0.02–616.0)	0.842
Taurine	0.55 (0.16–1.58)	0.50 (0.08–2.39)	0.763	0.52 (0.24–1.58)	0.50 (0.08–2.39)	0.512
Myo-inositol	1.21 (0.27–4.71)	1.40 (0.24–4.25)	0.652	1.14 (0.27–4.71)	1.25 (0.24–4.25)	0.798
Glycine	0.14 (0.04–0.98)	0.14 (0.04–2.06)	0.585	0.11 (0.04–0.98)	0.15 (0.04–2.06)	0.992
Phosphoethanolamine	0.35 (0.05–0.1.88)	0.54 (0.11–1.61)	0.560	0.31 (0.11–1.88)	0.44 (0.05–1.61)	0.992
Inosine	0.02 (0.00–0.13)	0.02 (0.00–0.12)	0.301	0.02 (0.00–0.13)	0.02 (0.00–0.13)	0.909
Tyrosine	0.02 (0.00–0.16)	0.02 (0.00–0.44)	0.893	0.02 (0.01–0.16)	0.02 (0.00–0.44)	0.270
Hypoxanthine	0.02 (0.00–0.16)	0.04 (0.01–0.51)	0.293	0.03 (0.01–0.16)	0.02 (0.00–0.51)	0.585
Formate	0.20 (0.01–0.89)	0.13 (0.00–0.48)	0.185	0.19 (0.05–0.89)	0.15 (0.00–0.48)	0.275
Succinate	0.02 (0.01–0.76)	0.03 (0.00–0.52)	0.297	0.02 (0.01–0.76)	0.02 (0.00–0.52)	0.790
Uridine	0.01 (0.00–0.02)	0.01 (0.00–0.02)	0.917	0.01 (0.00–0.02)	0.01 (0.00–0.23)	0.551

Note–Unless otherwise specified, the data are the medians (range).

LN, lymph node.