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. 2016 Apr 20;139(5):1325–1347. doi: 10.1093/brain/aww050

Figure 2.

Figure 2

Ability of methylphenidate and modafinil to reverse the effects of TBZ in rats responding on the concurrent FR5/chow choice task. All rats (adult male, Sprague-Dawley rats, Harlan Sprague-Dawley) were trained as described in Yohn et al. (2016 a ), and tested in 30-min sessions. Rats were tested 5 days/week, and drug testing was conducted 1 day each week, with a randomized order of drug treatments. ( A ) Methylphenidate. Rats ( n = 12) received intraperitoneal (IP) injections of vehicle or 0.75 mg/kg of TBZ 90 min prior to testing, and also received intraperitoneal injections of vehicle or methylphenidate 45 min prior to testing. Top : Mean [± standard error of the mean (SEM)] number of lever presses. There was an overall significant effect of drug treatment on lever pressing [ F (5,55) = 14.7, P < 0.001]. Planned comparisons showed that TBZ significantly decreased lever pressing compared to vehicle ( #P < 0.05), and that all doses of methylphenidate plus TBZ significantly increased lever pressing relative to TBZ plus vehicle ( **P < 0.01). Bottom : Mean (±SEM) gram quantity of chow intake. There was an overall significant effect of drug treatment on chow intake [ F (5,55) = 19.6, P < 0.001]. Planned comparisons showed that TBZ significantly increased chow consumption relative to vehicle ( #P < 0.05), and that all doses of methylphenidate plus TBZ significantly decreased chow intake relative to TBZ plus vehicle ( **P < 0.01). ( B ) Modafinil. Rats ( n = 12) received intraperitoneal injections of vehicle or 0.75 mg/kg of TBZ 90 min prior to testing, and intraperitoneal injections of either vehicle or modafinil 30 min prior to testing. Top : Mean (±SEM) number of lever presses. There was an overall significant effect of drug treatment on lever pressing [ F (5,55) = 21.0, P < 0.001]. Planned comparisons showed that TBZ significantly decreased lever pressing compared to vehicle ( #P < 0.05), and that the 7.5–30.0 mg/kg doses of modafinil plus TBZ significantly increased lever pressing relative to TBZ plus vehicle (* P < 0.05; **P < 0.01). Bottom : Mean (±SEM) gram quantity of chow intake. There was an overall significant effect of drug treatment on chow intake [ F (5,55) = 14.1, P < 0.001]. Planned comparisons showed that TBZ significantly increased chow consumption relative to vehicle ( #P < 0.05), and that the 7.5–30.0 mg/kg doses of modafinil plus TBZ significantly increased lever pressing relative to TBZ plus vehicle (* P < 0.05; **P < 0.01). Results are from the unpublished thesis of Augustyna Gojol, University of Connecticut, 2015.