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. 2017 Mar 9;16(2):163–172. doi: 10.2450/2017.0230-16

Figure 2.

Figure 2

Changes in the number of red blood cell (RBC)-derived extracellular vesicels (REV)/μL detected by flow cytometry during RBC storage.

There was an exponential increase of the number of REV during storage in each RBC concentrate. Annexin V+ REV are shown in (A) and annexin V− REV in (B). Each line corresponds to one RBC concentrate. The results are expressed as the ratio between the number of REV/μL at Dx and the number of REV/μL at D0 (logarithmic scale), thus showing the relative increase of the number of REV at different time-points of storage compared to the number of REV on the day the RBC were collected. A plateau is reached around D28 and towards the end of storage period. Depending on the RBC concentrate analysed, the number of annexin V+ REV increased by 83- to 469-fold during storage while the number of annexin V− REV increased by 27- to 108-fold.