Table I.

Evolution of the four parameters of thrombin generation during storage.

	D0: mean±SD (min.–max.)	D42: mean±SD (min.–max.)	Global evolution (min.–max.)
Peak (nM)	27.8±6.8 (15.6–37.3)	370.6±21.6 (323.7–402.1)	Increase of 12.9 (9.9–20.7) times
ETP (nM)	440.2±130.0 (219.7–654.7)	1,347.6±85.4 (1,203.7–1,492.0)	Increase of 2.8 (2.1–5.5) times
Lag time (min)	23.2±4.0 (18.3–30.2)	7.3±0.9 (6.2–9.1)	Decrease of 3.1 (2.6–4.1) times
Time to peak (min)	29.0±4.0 (23.6–36.0)	9.3±1.0 (8.0–11.2)	Decrease of 3.1 (2.7–3.8) times

During storage of the 12 RBC concentrates, there was a 12.9-fold increase in peak of thrombin generated, a 2.8-fold increase in the endogenous thrombin potential (ETP), and 3.1-fold decreases of both the lag time and time to peak in the calibrated automated thrombogram assay. The mean values and standard deviations (SD) are indicated. The minimum (min.) and maximum (max.) values are included in parentheses.