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. 2018 Jan 30;159(3):1537–1546. doi: 10.1210/en.2017-03176

Figure 5.

Figure 5.

Blockade of NMDARs reduces the hyperactivity of PVN-CRH neurons in CUMS rats. Representative raw traces and a histogram of firing rates show the effect of 50 µM AP5 on the spontaneous firing rate of labeled PVN-CRH neurons of (A) unstressed and (B) CUMS rats. Summary data show the effects of 50 µM AP5 on the (C) firing rates and (D) membrane potentials of PVN-CRH neurons of unstressed (n = 8 neurons) and CUMS rats (n = 8 neurons). *P < 0.05 compared with the corresponding value in the unstressed group; #P < 0.05 compared with the basal values in CUMS rats.