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. 2018 Mar 6;7:e31715. doi: 10.7554/eLife.31715

Figure 6. Schematic for the mechanism of the functional rotation.

Figure 6.

Relative motions of the transmembrane domain (consisting of R1 and R2 repeats, and TM2 and TM8) and the porter domain (consisting of the PN1, PN2, PC1 and PC2 subdomains) are represented by thick black arrows. The coil-to-helix and reverse helix-to-coil transitions in TM8 are also indicated by thick black arrows. The accessibility of protons/drug to the TM/porter domain is indicated by small black arrows with broken lines. The funnel domain is omitted for visual clarity.