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. 2018 Mar 5;215(3):963–983. doi: 10.1084/jem.20170123

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© 2018 Kim et al.

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Figure 1. — Abnormal vessels in HGG have distinct endothelial transcripts. (A–H) H&E staining (A) and CD31-positive vessels (B–H) in nontumor brain and orthotopic HGG. (B–E) Vascular network (B) and quantification of vessel area (C), vessel number based on vessel diameter (D), and vessel branching (E). (F) PDGFRβ-positive pericytes and quantification of coverage. (G) Evans blue (EB) and quantification of extravasation. (H) Lectin and quantification of vascular perfusion. Values are presented as mean ± SD (n = 5). **, P < 0.01. (I–L) Transcriptome analyses of normal brain and HGG ECs by RNA sequencing (n = 3). (I–K) Heat map (I), top five canonical pathways by the ingenuity pathway analysis (IPA; J), and top five gene ontology (GO) terms in biological processes (K) using 346 genes differentially expressed by more than twofold (P < 0.05). (L) Heat map of differentially expressed genes in the category of transcriptional regulation. (M) No Sox7 but robust Sox17 immunostaining in human nontumor brain vessels. (N and O) Sox7 immunostaining in tumor vessels from glioma patients with different grades (N) and intensity scores of nine grade II, six grade III, and nine grade IV patients (O) Bars, 100 µm.