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. 2018 Mar 5;215(3):963–983. doi: 10.1084/jem.20170123

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© 2018 Kim et al.

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Figure 2. — Sox7 is up-regulated in HGG vessels. (A–H) CD31-positive vessels in Sox7^mCh/+ and Sox17^GFP/+ mice. (A and B) Sox7-mCherry (A) and Sox17-GFP (B) fluorescence and signal quantification in nontumor brain and tumor vessels of mice bearing orthotopic GL261 HGG. (C and D) Sox7-mCherry and Sox17-GFP fluorescence in tumor vessels. GL261- and LLC-derived intracranial (C) and subcutaneous tumors (D). (E) Quantification of fluorescence signals in C and D. (F) Robust Sox7-mCherry and Sox17-GFP signals in brain vessels on embryonic day 10.5 (E10.5) and postnatal day 5 (P5). (G) Sox7 immunostaining and its quantification in Sox17-GFP–low and –high vessels in GL261 HGG. (H) Sox17 immunostaining and its quantification in Sox7-mCherry–high and –low vessels in GL261 HGG. (I) Sox7 and Sox17 immunostaining in tumor vessels using adjacent sections from the same HGG patients. Values are presented as mean ± SD (n = 5). **, P < 0.01. Bars: 100 µm (A–D and G–I); 50 µm (F).