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. 2018 Mar 5;215(3):963–983. doi: 10.1084/jem.20170123

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© 2018 Kim et al.

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Figure 5. — Sox7 up-regulation is responsible for further vascular abnormality in Sox17-deficient HGG vessels. (A and B) Sox7 (A) and Sox17 (B) immunostaining and quantification in HGG vessels of control, Sox7^iΔEC (S7KO), or Sox17^iΔEC (S17KO) mice. (C) GL261-GFP HGGs grown in control, S17KO, and Sox7/17^i△EC (DKO) mice and quantification of tumor volume (n = 10). (D–I) CD31-positive HGG vessels in control, S17KO, and DKO mice. (D) Vascular network and quantification of vessel area. (E and F) PDGFRβ-positive pericytes (E) and Col4-positive basement membrane (BM; F) and quantification of coverage. (G) Lectin and quantification of vascular perfusion. (H) Ter119-positive erythrocytes and quantification of hemorrhage. (I) GLUT1 immunostaining and quantification of hypoxic area. Values are presented as mean ± SD (n = 5 unless otherwise denoted). **, P < 0.01 versus control; ##, P < 0.01 versus Sox17^iΔEC. NS, not significant. Bars: 100 µm (A, B, and D–I); 2 mm (C).