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. 2018 Mar 5;215(3):859–876. doi: 10.1084/jem.20171440

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© 2018 Roche Diagnostics GmbH

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Figure 5. — CD40 is expressed on TAMs of cancer patients. (A) Exemplary IHC images for CD163 and CSF-1R staining and duplex staining for CD68/CD40 staining of one exemplary CRC and one exemplary mesothelioma patient. Black arrowheads indicate examples of CD68⁺CD40⁺ double-positive macrophages. (B) Overall correlation shown as heat maps of 9 CRC and 19 mesothelioma patients using data obtained by automated digital analyses. (C) CD68⁺CD40⁺ double-positive cells in CRC and mesothelioma patients quantified as cell counts per squared millimeters of tumor tissue by digital analyses. (D) CSF-1R⁺ macrophages and CD3⁺ T cells colocalize in CRC and mesothelioma as assessed from consecutive sections.