Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Mar 5;215(3):895–910. doi: 10.1084/jem.20171818

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 Shee et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 6. — FGF2 signaling is associated with poor disease outcome and anti–estrogen resistance in patients with ER+ breast cancer. (A) MCF-7 and T47D cells were pretreated with 1 µM fulv for 24 h and then treated with or without 25 ng/ml FGF2 for 1 h in triplicate, and RNA sequencing was performed to generate a signature of FGF2 response. Heatmap of differentially expressed genes common between MCF-7 and T47D (P < 0.05) in response to FGF2 treatment. (B–E) RNA-sequencing data were used to derive FGF2 pathway activation scores for each human primary breast tumor from four independent datasets containing information from 1,390 (B), 164 (C), 298 (D), and 202 (E) patients. Patients with tumors exhibiting positive versus negative scores were compared by log-rank test using RFS (B–D) or OS (E).