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. 2018 Mar 5;215(3):841–858. doi: 10.1084/jem.20171971

Figure 5.

Figure 5.

Neither IFNγ nor IL17A was required for initiation of inflammatory tumorigenesis by CTLA4 insufficiency. (A) Anti-CTLA4 antibodies were administered to IFNγo or IFNγ+ mice on the BALB/c genetic background for 4 wk. The control Ig or vehicle treatment group was a pool of both IFNγ+ and IFNγo mice. The animals were analyzed 1 wk after the mAb treatment. Representative gastric histopathology images (bars, 100 µm) are followed with a summary of pathology scores. Data represent four or five mice per group pooled from two experiments (mean ± SEM; Kruskal–Wallis test). (B) CTLA4KD IL17Ao, CTLA4KD IL17A+, or wild-type littermates were analyzed at 7–26 wk of age. Representative gastric histopathology images (bars, 100 µm) are followed with a summary of pathology scores. Data represent five mice per group pooled from two experiments. Each data point represents one animal (mean ± SEM; Kruskal–Wallis test). *, P < 0.05; **, P < 0.01; ns, not significant.